Pharmacology: Pharmacokinetics: Lamotrigine is well-absorbed from the gastrointestinal tract and peak plasma concentrations (Cmax) occur approximately 2.5 hrs after oral dose. It is widely distributed in the body and is reported to be about 55% bound to plasma proteins. It is extensively metabolized in the liver and excreted almost entirely conjugate. It slightly induces its own metabolism and the t½ at conjugate. It slightly induces its own metabolism and the t½ in urine, principally as a glucuronide conjugate. It slightly induces its own metabolism and the t½ at steady state is reported to be about 24 hrs. Lamotrigine is distributed in breast milk.
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